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Literature summary for 1.14.11.4 extracted from
- Collagen cross-linking mediated by lysyl hydroxylase 2 an enzymatic battlefield to combat fibrosis (2019), Essays Biochem., 63, 377-387 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [procollagen]-L-lysine + 2-oxoglutarate + O2 | Homo sapiens | - |
[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00469 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [procollagen]-L-lysine + 2-oxoglutarate + O2 | - |
Homo sapiens | [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | in order to be active the ezyme (LH2) needs to form homodimers | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LH2 | - |
Homo sapiens |
| lysyl hydroxylase 2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| drug target | normalizing the cross-link pattern by selectively inhibiting LH2 (and thus hydroxy-alpha-aminoadipic acid-delta-semialdehyde cross-linking) alters the balance of collagen degradation. It is expected that this results in reversible fibrosis. Since the up-regulation of LH2 is seen in all organs, a drug that specifically inhibits LH2 activity can be used in a wide range of fibrotic disorders. Since LH2 catalyzes only a single reaction downstream in the fibrogenic cascade (namely the formation of unwanted cross-links in collagen of the fibrotic lesions), little (if any) side-effects are expected, as the deposited collagen in the wound area is expected to be normally modified, and thus have the properties (e.g. with respect to tensile strength) required for a normal function of the repaired tissue | Homo sapiens |
| physiological function | lysyl hydroxylase 2 is responsible for the formation of telopeptidyl hydroxylysine, leading to the formation of hydroxy-alpha-aminoadipic acid-delta-semialdehyde cross-links by lysyl oxidases. The enzyme is universally up-regulated in fibrosis | Homo sapiens |
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